Focus on Research: Ion transporters in the kidney (Part 1)

Part 1 of 2

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Hui Cai, MD

Dr. Hui Cai, an assistant professor of medicine in the Emory Division of Renal Medicine, studies the regulation of sodium potassium 2 chloride (NKCC) cotransporters in various models of hypertension.

Dr. Cai investigates the role(s) of WNK kinase in the regulation of the NKCC cotransporter and the Maxi K channel in the kidney. His research, which has been supported by NIH and AHA funding, aims to elucidate the molecular mechanism underlying PHA II, also referred to as Gordon syndrome. Gordon syndrome is characterized by hypertension, an excess of potassium, and metabolic acidosis.

Although sodium is essential for healthy bodily functions, too much sodium can be harmful for people with kidney disease, because their kidneys cannot eliminate excess sodium and fluid from the body. As sodium and fluid build up in their tissues and bloodstream, their blood pressure increases. The Cai lab hopes to provide novel insight into the development of essential hypertension.

More about Dr. Cai

Hui Cai, MD is an assistant professor of medicine in the Emory University Division of Renal Medicine. He received his MD from Wenzhou Medical College (China). He received residency training at Wenzhou Medical College and nephrology training at Hua Shan Hospital (China). In 1992, Dr. Cai came to Louisiana State University (LSU) Medical Center and Tulane University for his postdoctoral fellow training. He went on to complete internal medicine residency training at Brookdale University Hospital (New York) in 1997 and nephrology fellowship training at Johns Hopkins University in 2000, where he later became a faculty member. Dr. Cai has worked within the Emory University School of Medicine since 2007.

*If you are interested in investing in research, clinical care, and/or education within the Emory University School of Medicine’s Division of Renal Medicine, please visit our website to learn how you can help.

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