“STING Signaling and Inflammatory Diseases”: February 9

Hiroyasu Konno, PhD

Please join the Emory University Department of Medicine’s Division of Rheumatology on Thursday, February 9, 2017 at 4 p.m. for “STING Signaling and Inflammatory Diseases,” a seminar by Hiroyasu Konno, PhD (Senior Research Associate, University of Miami School of Medicine, Sylvester Comprehensive Cancer Center).

Dr. Konno will discuss the molecular mechanisms of stimulator of interferon genes (STING) signaling, especially focusing on STING trafficking and how activated STING triggers inflammatory diseases. Additionally, Dr. Konno will discuss the challenges related to finding STING inhibitors.


Date: Thursday, February 9, 2017
Time: 4 p.m.
Location: Whitehead Auditorium, Whitehead Research Building

Dr. Konno’s Abstract
The innate immunity triggers inflammation including the production of type I interferon (IFN) and inflammatory cytokines to protect us from pathogen infection. On the other hand, innate immunity causes inflammatory diseases when self-molecules such as nucleic acids are detected by innate immune receptors. Stimulator of interferon genes (STING), which is involved in innate immunity, activates inflammation in response to pathogen-derived DNA. On the other hand, recent accumulating evidence has shown that activated STING pathway by self-DNA causes inflammatory diseases such as rheumatoid arthritis, lupus, and inflammation-driven cancer. In addition, gain-of-function mutations in STING gene cause STING-associated vasculopathy with onset in infancy (SAVI). STING is in the endoplasmic reticulum (ER) as a dimer under normal conditions but moves to the peri-nuclear area to activate downstream signals. This is known as STING trafficking that is the hallmark of STING activation. During the seminar, I will talk about the molecular mechanisms of STING signaling, especially focusing on STING trafficking, and how activated STING triggers inflammatory diseases. In addition, I will show you our challenge to find STING inhibitors.

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About the Author

Emory Department of Medicine
Emory Department of Medicine
The Emory University Department of Medicine, within the Emory University School of Medicine, is steeped in a rich tradition of excellence. Through the work of its nine divisions and numerous centers and institutes, the department has pioneered discoveries in medicine, education, scientific and clinical investigation, and clinical care. Emory University School of Medicine's medical school, residency, transitional-year, and fellowship programs offer students the latest knowledge in treatment practices, scientific theories, research, and patient care. The Emory University Department of Medicine is a component of the Robert W. Woodruff Health Sciences Center of Emory University, which includes the Emory schools of Medicine, Nursing, and Public Health; Yerkes National Primate Research Center; Winship Cancer Institute; and Emory Healthcare.

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