Featured Researcher: Clintoria Williams

Clintoria Williams, PhD

Clintoria R. Williams, PhD

Clintoria R. Williams, PhD is a renal physiologist in the Emory University Division of Renal Medicine. Dr. Williams’ research interests focus on the pathophysiology of kidney disease. Her work has identified a key functional difference in the isoforms of calcineurin, a family of ubiquitous calcium-dependent enzymes. These enzymes contribute to the regulation of sodium channels in the distal nephron of the kidney and, subsequently, blood-pressure homeostasis. Notably, patients that take calcineurin inhibitors for immuno-suppression frequently develop hypertension.

Since current drugs that inhibit calcineurin do not discriminate between the isoforms of the enzyme, there is an opportunity to refine pharmacological interventions to selectively target calcineurin isoform(s) implicated in the immune system versus isoform(s) involved in sodium regulation by the kidney. Recently, Dr. Williams received American Heart Association funding on her project, “Selective Regulation of Distal Nephron Sodium Handling by Calcineurin Isoforms.”

 

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About the Author

Emory Department of Medicine
Emory Department of Medicine

The Emory University Department of Medicine, within the Emory University School of Medicine, is steeped in a rich tradition of excellence. Through the work of its nine divisions and numerous centers and institutes, the department has pioneered discoveries in medicine, education, scientific and clinical investigation, and clinical care. Emory University School of Medicine’s medical school, residency, transitional-year, and fellowship programs offer students the latest knowledge in treatment practices, scientific theories, research, and patient care.

The Emory University Department of Medicine is a component of the Robert W. Woodruff Health Sciences Center of Emory University, which includes the Emory schools of Medicine, Nursing, and Public Health; Yerkes National Primate Research Center; Winship Cancer Institute; and Emory Healthcare.

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