Featured Researcher: Salim Thabet

thabet-salim

Salim Thabet, MD (Cardiology)

Salim Thabet, MD is a clinical fellow in the Emory University Division of Cardiology working with Dr. Hanjoong Jo, whose lab investigates vascular flow and endothelial function. Over the past two years, Dr. Thabet has studied the effect of disturbed blood flow, which is closely associated with atherosclerosis — or hardening of blood vessels — on endothelial gene expression and function. He is particularly interested in the Kruppel-like factor 3 (Klf-3) gene, which is a repressor of other genes and involved in certain forms of cancer and red blood cells as well as far cells formation. Klf-3 is down-regulated under conditions of disturbed flow; however, its role in atherosclerosis and arterial plaque formation has never been studied. Dr. Thabet’s experiments suggest that it plays important roles in inflammation, proliferation, and endothelial cell survival. Other experiments suggest that genetically modified mice lacking Klf3 seem to be protected from disturbed flow atherosclerosis formation.

Learn more about Dr. Jo’s lab and their research on the lab website.

In his free time, Dr. Thabet enjoys sports and spending time with his family.

 

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About the Author

Emory Department of Medicine
Emory Department of Medicine

The Emory University Department of Medicine, within the Emory University School of Medicine, is steeped in a rich tradition of excellence. Through the work of its nine divisions and numerous centers and institutes, the department has pioneered discoveries in medicine, education, scientific and clinical investigation, and clinical care. Emory University School of Medicine’s medical school, residency, transitional-year, and fellowship programs offer students the latest knowledge in treatment practices, scientific theories, research, and patient care.

The Emory University Department of Medicine is a component of the Robert W. Woodruff Health Sciences Center of Emory University, which includes the Emory schools of Medicine, Nursing, and Public Health; Yerkes National Primate Research Center; Winship Cancer Institute; and Emory Healthcare.

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