Date: Wednesday, November 4
Time: 8 a.m. to 3 p.m.
Location: Emory University School of Medicine, Room 190P
- To summarize known chemical and biological interactions of the toxic environmental metal cadmium (Cd) and the essential nutrient selenium (Se)
- To identify gaps in knowledge concerning health interactions of Cd and Se
- To discuss potential paths forward to address the gaps in knowledge
- Elias Arner, PhD, Professor of Biochemistry, Karolinska Institute
- Maria Kippler, PhD, Assistant Professor of Environmental Medicine, Karolinska Institute
- Helena Skroder, PhD candidate, Karolinska Institute
- Bruce Fowler, PhD, Adjunct Professor of Public Health, Emory University
- Raymond Burk, MD, Professor of Medicine and Pathology, Vanderbilt University
- Terrance Kavanagh, PhD, Professor, Environmental & Occupational Health Sciences, University of Washington
- Trent Tipple, MD, Associate Professor of Medicine, the University of Alabama at Birmingham
- Vadim Gladyshev, PhD, Professor of Medicine, Harvard University
- Kurt Pennell, PhD, Professor of Civil and Environmental Engineering, Tufts University
- Young-Mi Go, PhD, Assistant Professor of Medicine, Emory University
- Dean Jones, PhD, Professor of Medicine, Emory University
- 8:20-8:30 a.m. – Opening statement; Dean Jones
- 8:30-10 a.m. – What are the key issues for dietary Cd and Se exposures?
- 8:30-8:45 a.m. – Raymond Burk: Nutritional selenium status affects xenobiotic toxicity and injury by deficiencies of other antioxidant nutrients
- 8:45-9 a.m. – Bruce Fowler: CdSe Interactions-Current Status, Challenges and Prospects for the Future
- 9-9:15 a.m. – Maria Kippler: Health effects of early life Cd exposure
- 9:15-10 a.m.
- 10-10:15 a.m. – Break
- 10:15 a.m. to 12:15 p.m. – What potential mechanisms impact Cd-Se interaction in health and diseases?
- 10:15-10:30 a.m. – Vadim Gladyshev: Omics approaches to Se and Cd in mammals
- 10:30-10:45 a.m. – Helena Skroder: The role of Se in early child development interactions with toxic metals
- 10:45-11 a.m. – Trent Tipple: TrxR inhibition to prevent lung injury: interplay with Cd and Se
- 11-11:15 a.m. -Kurt Pennell: Cd-Se nanoparticles
- 11:15-12:15 p.m. – Discussion
- 12:15-1:30 p.m. – Lunch
- 1:30-3 p.m. – What are the research opportunities?
- 1:30-1:45 p.m. – Young-Mi Go: Low dose Cd effects on lung redox proteome
- 1:45-2 p.m. – Terrance Kavanagh: Effects of cadmium on gene expression in mice with compromised glutathione synthesis
- 2-2:15 p.m. – Elias Arner: Selenium biochemistry and the thioredoxin system
- 2:15-3 p.m. – Discussion